8. ImageChops difference

See: https://pillow.readthedocs.io/en/stable/reference/ImageChops.html#PIL.ImageChops.difference

8.1. Difference

Use the ImageChops.difference(image1, image2) method to return the absolute value of the pixel-by-pixel difference between the two images.
out = abs(image1 - image2)
from PIL import Image, ImageChops


with Image.open("test_images/crosses.png") as im1:
    with Image.open("test_images/circles.png") as im2:
        im_out = ImageChops.difference(im1, im2)
        im_out.save("chops/difference.png")
../_images/compare_difference.png